Functional and structural characterization of anti-β1-adrenoceptor autoantibodies of spontaneously hypertensive rats

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Item Type:	Article
Title:	Functional and structural characterization of anti-β1-adrenoceptor autoantibodies of spontaneously hypertensive rats
Creators Name:	Wallukat, G., Podlowski, S., Nissen, E., Morwinski, R., Csonka, C., Tosaki, A. and Blasig, I.E.
Abstract:	Eighteen month old spontaneously hypertensive rats (SHR-rats) showed myocardial dysfunction and autoantibodies directed against the {beta} 1-adrenoceptor similarly as known in human dilated cardiomyopathy or Chagas' disease. The agonist-like antibodies were able to activate the {beta} 1,-adrenoceptor mediated signal transduction cascade in cultured rat cardiomyocytes and induced a long-lasting stimulatory effect resulting in a harmful adrenergic overdrive. The antibodies recognized an epitope of the second extracellular loop of the {beta} 1-adrenoceptor identical to that epitope identified in Chagas' disease. In conclusion, our assumption is supported that old SHR-rat are an useful animal model for investigating the role of anti-{beta} 1-adrenoceptor antibodies in the induction of human cardiomyopathy
Keywords:	{beta}1-Adrenoceptor, Autoantibodies, Spontaneously Hypertensive Rats, Heart Failure, Cardiomyocytes, Animals, Rats
Source:	Molecular and Cellular Biochemistry
ISSN:	0300-8177
Publisher:	Springer
Volume:	251
Number:	1-2
Page Range:	67-75
Date:	September 2003
Official Publication:	https://doi.org/10.1023/A:1025469515963
PubMed:	View item in PubMed

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