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| Item Type: | Article |
|---|---|
| Title: | A critical requirement of interferon gamma-mediated angiostasis for tumor rejection by CD8T cells |
| Creators Name: | Qin, Z.H., Schwartzkopff, J., Pradera, F., Kammertoens, T., Seliger, B., Pircher, H. and Blankenstein, T. |
| Abstract: | It is thought that tumor rejection by CD8+ T-cell effectors is primarily mediated by direct killing. We show that rejection of different tumors (fibrosarcoma, ras-transformed fibroblasts, colon carcinoma, and plasmacytoma) by CD8+ T cells is always preceded by inhibition of tumor-induced angiogenesis. Angiostasis and tumor rejection were observed in perforin but not in IFN-γ-deficient mice. Furthermore, adoptive transfer of tumor-specific CD8+ T cells from IFN-γ-competent mice inhibited angiogenesis of lung metastases in comparison to those from IFN-γ gene-deficient mice. Taken together with our previous findings, we conclude that IFN-γ-dependent antiangiogenesis is a general mechanism involved in tumor rejection by CD4+ and CD8+ T-cell effectors. |
| Keywords: | Ascitic Fluid, Chromium Radioisotopes, Experimental Neoplasms, Fibrosarcoma, Histocompatibility Antigens, Immunologic Cytotoxicity, Inbred C57BL Mice, Kinetics, Methylcholanthrene, Neoplasm Antigens, P.H.S. U.S. Govt Support, T-Lymphocytes, Animals, Mice |
| Source: | Cancer Research |
| ISSN: | 0008-5472 |
| Publisher: | American Association for Cancer Research |
| Volume: | 63 |
| Number: | 14 |
| Page Range: | 4095-4100 |
| Date: | 1 January 2003 |
| Official Publication: | http://cancerres.aacrjournals.org/cgi/content/abstract/63/14/4095 |
| PubMed: | View item in PubMed |
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