Enriched environment and physical activity stimulate hippocampal but not olfactory bulb neurogenesis

Tools

Item Type:	Article
Title:	Enriched environment and physical activity stimulate hippocampal but not olfactory bulb neurogenesis
Creators Name:	Brown, J., Cooper-Kuhn, C.M., Kempermann, G., van Praag, H., Winkler, J., Gage, F.H. and Kuhn, H.G.
Abstract:	Exposure to an enriched environment and physical activity, such as voluntary running, increases neurogenesis of granule cells in the dentate gyrus of adult mice. These stimuli are also known to improve performance in hippocampus-dependent learning tasks, but it is unclear whether their effects on neurogenesis are exclusive to the hippocampal formation. In this study, we housed adult mice under three conditions (enriched environment, voluntary wheel running and standard housing), and analysed proliferation in the lateral ventricle wall and granule cell neurogenesis in the olfactory bulb in comparison to the dentate gyrus. Using bromodeoxyuridine to label dividing cells, we could not detect any difference in the number of newly generated cells in the ventricle wall. When giving the new cells time to migrate and differentiate in the olfactory bulb, we observed no changes in the number of adult-generated olfactory granule cells; however, voluntary running and enrichment produced a doubling in the amount of new hippocampal granule cells. The discrepancy between the olfactory bulb and the dentate gyrus suggests that these living conditions trigger locally through an as yet unidentified mechanism specific to neurogenic signals in the dentate gyrus.
Keywords:	Environmental Stimulation, Exercise, Mouse, Proliferation, Animals, Mice
Source:	European Journal of Neuroscience
ISSN:	0953-816X
Publisher:	Blackwell Publishing
Volume:	17
Number:	10
Page Range:	2042-2046
Date:	May 2003
Official Publication:	https://doi.org/10.1046/j.1460-9568.2003.02647.x
PubMed:	View item in PubMed

Repository Staff Only: item control page