![[feed]](/style/images/feed-icon-14x14.png){kind=icon}
Tools
Tools
![[thumbnail of 5908oa.pdf]](https://edoc.mdc-berlin.de/style/images/fileicons/application_pdf.png) |
PDF
- Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
171kB |
| Item Type: | Article |
|---|---|
| Title: | SMART: identification and annotation of domains from signalling and extracellular protein sequences |
| Creators Name: | Ponting, C.P., Schultz, J., Milpetz, F. and Bork, P. |
| Abstract: | SMART is a simple modular architecture research tool and database that provides domain identification and annotation on the WWW (http://coot.embl-heidelberg.de/SMART). The tool compares query sequences with its databases of domain sequences and multiple alignments whilst concurrently identifying compositionally biased regions such as signal peptide, transmembrane and coiled coil segments. Annotated and unannotated regions of the sequence can be used as queries in searches of sequence databases. The SMART alignment collection represents more than 250 signalling and extracellular domains. Each alignment is curated to assign appropriate domain boundaries and to ensure its quality. In addition, each domain is annotated extensively with respect to cellular localisation, species distribution, functional class, tertiary structure and functionally important residues. |
| Keywords: | Amino Acid Sequence, Factual Databases, Information Storage and Retrieval, Membrane Proteins, Protein Sorting Signals, Tertiary Protein Structure, Proteins, Sequence Alignment, Amino Acid Sequence Homology, Signal Transduction, User-Computer Interface |
| Source: | Nucleic Acids Research |
| ISSN: | 0305-1048 |
| Publisher: | Oxford University Press |
| Volume: | 27 |
| Number: | 1 |
| Page Range: | 229-232 |
| Date: | 1 January 1999 |
| Official Publication: | http://nar.oxfordjournals.org/cgi/content/abstract/27/1/229 |
| PubMed: | View item in PubMed |
Repository Staff Only: item control page
