Effects of low density lipoproteins on endothelial cell signaling and adhesion molecule expression

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Item Type:	Book Section
Title:	Effects of low density lipoproteins on endothelial cell signaling and adhesion molecule expression
Creators Name:	Haller, H. and Luft, F.C.
Abstract:	Endothelial cell activation plays an important role in the physiological regulation of healthy and diseased blood vessels (1). Endothelial cell intracellular free calcium concentration [Ca2+]i is an important mediator of this activation (2). Hypercholesterolemia, particularly the low-density lipoprotein (LDL) fraction, is an important risk factor for the development of atherosclerosis, a disease process intimately involving endothelial cells (3). LDL stimulates endothelial cell [Ca2+]i (receptor mediated), promotes the release of prostacyclin (PGI), and facilitates inactivation of endothelial-derived relaxing factor (EDRF) or nitric oxide (NO) (4,5). LDL also stimulates [Ca2+]i in vascular smooth muscle cells (VSMC) (6,7), and in cardiac myocytes (8).
Title of Book:	Contemporary Endocrinology: Endocrinology of the Vasculature
Publisher:	Humana Press
Volume:	1
Page Range:	173-184
Date:	1996
Official Publication:	https://doi.org/10.1007/978-1-4612-0231-8_13

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