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| Item Type: | Article |
|---|---|
| Title: | Nitric oxide signals parallel fiber activity to Bergmann glial cells in the mouse cerebellar slice |
| Creators Name: | Matyash, V., Filippov, V., Mohrhagen, K. and Kettenmann, H. |
| Abstract: | Stimulation of parallel fibers in the cerebellar cortex triggers a transient calcium increase in Bergmann glial cells, a special form of astrocytes. Using patch-clamping and imaging techniques we have found that this form of neuron-gila interaction is mediated by nitric oxide (NO) since the response is blocked by the NO-synthase inhibitor Nω-nitro-L-arginine and mimicked by NO donors. None of the neurotransmitter receptors of Bergmann gila identified so far participates in or interferes with this signaling cascade. The NO-triggered increases in [Ca2+]i, as studied in Bergmann glial cells in the slice or in cultured astrocytes, are due to Ca2+ influx and not to release from cytoplasmic stores. Thus, NO released from parallel fibers serves as a signaling substance to the neighboring glial elements. |
| Keywords: | Action Potentials, Axons, Calcium, Calcium Signaling, Cell Communication, Cerebellar Cortex, Cultured Cells, Cytoplasm, Electric Stimulation, Enzyme Inhibitors, Fluorescent Dyes, Fura-2, Inbred Strains Mice, Neuroglia, Neurotransmitter Receptors, Nitric Oxide, Nitric Oxide Donors, Nitric Oxide Synthase, Organ Culture Techniques, Animals, Mice |
| Source: | Molecular and Cellular Neuroscience |
| ISSN: | 1044-7431 |
| Publisher: | Academic Press |
| Volume: | 18 |
| Number: | 6 |
| Page Range: | 664-670 |
| Date: | December 2001 |
| Official Publication: | https://doi.org/10.1006/mcne.2001.1047 |
| PubMed: | View item in PubMed |
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