Salvage therapy for relapsed mediastinal B-cell lymphoma with allogeneic HLA-identical related donor bone marrow transplantation, donor lymphocyte infusion and IDEC-C2B8

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Item Type:	Article
Title:	Salvage therapy for relapsed mediastinal B-cell lymphoma with allogeneic HLA-identical related donor bone marrow transplantation, donor lymphocyte infusion and IDEC-C2B8
Creators Name:	Ratei, R., Matylis, A., Krahl, D., Arnold, R., Stein, H., Doerken, B. and Ludwig, W.D.
Abstract:	Primary B-cell lymphoma of the mediastinum is an aggressive non-Hodgkin's lymphoma with distinct clinicopathologic features. Response rates are between 60-80% following intensive chemotherapy regimens. Poor responders or patients with an early relapse usually do not achieve a prolonged second remission with conventional salvage therapy protocols and therefore qualify for intensive or experimental approaches. Here we describe two patients of same age, gender and stage with primary mediastinal B-cell lymphoma and an early relapse after the first courses of combination chemotherapy and irradiation of the mediastinum. One patient relapsed after a salvage therapy with allogeneic donor-related bone marrow transplantation and donor lymphocyte infusion but responded again with a continuing good partial remission after infusion of the chimeric anti-CD20 antibody IDEC-C2B8. For the other patient an allogeneic bone marrow transplantation was not possible. He finally failed to respond to salvage therapy with IDEC-C2B8 and died of progressive disease. The anti-CD20 antibody IDEC-C2B8 induced a partial remission in a patient with primary mediastinal B-cell lymphoma refractory to other therapeutic approaches, including allogeneic bone marrow transplanatation (alloBMT), donor lymphocyte infusion (DLI) and irradiation. The role of IDEC-C2B8 as a component of salvage regimens appears to be worthy for further evaluation in high-risk patients with primary mediastinal B-cell lymphoma.
Keywords:	Primary Mediastinal B-Cell Lymphoma, Salvage Therapy, Allogeneic Donor Related Bone Marrow Transplantation, Donor Lymphocyte Infusion, Anti-CD20 Antibody, IDEC-C2B8
Source:	Leukemia & Lymphoma
ISSN:	1042-8194
Volume:	40
Number:	1-2
Page Range:	133-140
Date:	December 2000
Official Publication:	https://doi.org/10.3109/10428190009054890
PubMed:	View item in PubMed

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