Origin, structure and motifs of naturally processed MHC class II ligands

Tools

Item Type:	Review
Title:	Origin, structure and motifs of naturally processed MHC class II ligands
Creators Name:	Roetzschke, O. and Falk, K.
Abstract:	In the past few years a considerable number of naturally processed MHC class II ligands have been identified and sequenced. Most of them derive from endogenous sources, predominantly from plasma membrane proteins. Generally, they display variability in length but exhibit characteristic patterns of invariant amino acid positions, which reflect the allele-specific binding requirements. As a general feature, class II ligands also often contain a pattern of proline residues interpreted as a 'processing motif'.
Keywords:	Amino Acid Sequence, Binding Sites, Epitopes, Evolution, Histocompatibility Antigens Class II, Ligands, Molecular Sequence Data, Peptides, Animals
Source:	Current Opinion in Immunology
ISSN:	0952-7915
Publisher:	Elsevier
Volume:	6
Number:	1
Page Range:	45-51
Date:	February 1994
Official Publication:	https://doi.org/10.1016/0952-7915(94)90032-9
PubMed:	View item in PubMed

Repository Staff Only: item control page