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| Item Type: | Article |
|---|---|
| Title: | Peptide motifs of HLA-B51, -B52 and -B78 molecules, and implications for Behcet's disease |
| Creators Name: | Falk, K., Roetzschke, O., Takiguchi, M., Gnau, V., Stevanovic, S., Jung, G. and Rammensee, H.G. |
| Abstract: | Here we report peptide motifs of five HLA-B molecules, B*5101, B*5102, B*5103 B*5201 and B*7801. Motifs were obtained by pool sequencing of natural ligands eluted from the respective molecules expressed in C1R cells upon transfection. A number of individual ligands that could be sequenced confirmed the motifs. All five HLA-B molecules belong to the HLA-B5, B35-cross-reactive group and are closely related as indicated by similar sequences. B51 and B52 are associated with Bw4, whereas B78 is associated with Bw6. One of the HLA-B molecules investigated here, HLA-B*5101, is associated with Behçet's disease, a multisystemic inflammatory disease affecting various organs. This disease is especially frequent among the Japanese population. The subtle differences between the peptide motifs of B*5101 as compared with the motifs of the four other closely related but not disease-associated molecules could shed light on the nature of the HLA-association of Behçet's disease. |
| Keywords: | Disease Association, HLA-B51, HLA-B52, HLA-B78, HLA-B*5101, HLA-B*5102, HLA-B*5103, HLA-B*5201, HLA-B*7801, HLA class I, HLA Ligands, Pool Sequencing |
| Source: | International Immunology |
| ISSN: | 0953-8178 |
| Publisher: | Oxford University Press |
| Volume: | 7 |
| Number: | 2 |
| Page Range: | 223-228 |
| Date: | 1 February 1995 |
| Official Publication: | https://doi.org/10.1093/intimm/7.2.223 |
| PubMed: | View item in PubMed |
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