Involvement of inhibitory NKRs in the survival of a subset of memory-phenotype CD8+ T cells

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Item Type:	Article
Title:	Involvement of inhibitory NKRs in the survival of a subset of memory-phenotype CD8+ T cells
Creators Name:	Ugolini, S., Arpin, C., Anfossi, N., Walzer, T., Cambiaggi, A., Foerster, R., Lipp, M., Toes, R.E.M., Melief, C.J., Marvel, J. and Vivier, E.
Abstract:	Inhibitory natural killer receptors (NKRs) such as killer cell immunoglobulin-like receptors (KIRs) in humans and Ly49 molecules in mice are expressed on NK cells and recognize multiple major histocompatibility (MHC) class I proteins. In humans and mice, a subset of CD8 + T cells also expresses NKRs and harbors a memory phenotype. Using mice that are transgenic for K1R2DL3 and its cognate HLA-Cw3 ligand, we show that engagement of inhibitory NKRs selectively drives the in vivo accumulation of a subset of memory-phenotype CD8 + T cells that express the β chain of the interleukin 2 receptor. In vitro, recognition of MHC class I molecules by inhibitory NKRs on T cells down-regulated activation-induced cell death. These results unveil an MHC class I-dependent pathway that promotes the survival of a subset of memory-phenotype CD8 + T cells and also reveal an unexpected biological function for inhibitory NKRs on T cells.
Keywords:	CD8-Positive T-Lymphocytes, Cell Death, HLA-C Antigens, Immunologic Memory, Natural Killer Cells, Mice, Transgenic Mice, Phenotype, Immunologic Receptors, Spleen, T-Lymphocyte Subsets, Vaccination
Source:	Nature Immunology
ISSN:	1529-2908
Publisher:	Nature Publishing Group
Volume:	2
Number:	5
Page Range:	430-435
Date:	1 January 2001
Official Publication:	https://doi.org/10.1038/87740
PubMed:	View item in PubMed

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