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| Item Type: | Article |
|---|---|
| Title: | B-Myb, a repressed trans-activating protein |
| Creators Name: | Ansieau, S., Kowenz-Leutz, E., Dechend, R. and Leutz, A. |
| Abstract: | B-Myb belongs to a family of related transcription factors which share a unique DNA binding domain. B-Myb plays an important role in regulation of the cell cycle. Its expression is upregulated by the human papilloma virus HPV16 E7 oncoprotein. Overexpression of B-Myb can bypass p53-mediated cell cycle arrest. The founding member of the myb gene family, c-Myb, and A-Myb are involved in hematopoiesis and neurogenesis, respectively, and are both activators of gene transcription. Whether B-Myb is a transactivator or a repressor, however, has remained a matter of discussion. We reviewed the transactivation potential of B-Myb in yeast, taking advantage of the fact that inducible gene activation is an evolutionarily conserved process. By mutational analysis we localized a conserved activation domain in B-Myb. In vertebrate cells the transactivation potential of B-Myb is concealed by the C-terminal part of the protein. We show that the cell cycle regulators cyclin A and cyclin E activate B-Myb by eradicating the inhibition mediated by its carboxy-terminus. Our data suggest that in vertebrates the trans-activating function of B-Myb is regulated during the cell cycle and link Myb functions to cell cycle progression. |
| Keywords: | Transactivation, Cell Cycle, Cyclin, Transcription Factor, Animals, Chickens, Mice, Xenopus |
| Source: | Journal of Molecular Medicine |
| ISSN: | 0946-2716 |
| Publisher: | Springer |
| Volume: | 75 |
| Number: | 11-12 |
| Page Range: | 815-819 |
| Date: | November 1997 |
| Official Publication: | https://doi.org/10.1007/s001090050170 |
| PubMed: | View item in PubMed |
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