Tenascin-R associates extracellularly with parvalbumin immunoreactive neurones but is synthesised by another neuronal population in the adult rat cerebral cortex

Tools

Item Type:	Article
Title:	Tenascin-R associates extracellularly with parvalbumin immunoreactive neurones but is synthesised by another neuronal population in the adult rat cerebral cortex
Creators Name:	Wintergerst, E.S., Rathjen, F.G., Schwaller, B., Eggli, P. and Celio, M.R.
Abstract:	The molecular components surrounding a neurone serve as recognition cues for the nerve terminals and glial processes that contact them and the constellations formed by these inputs will therefore be determined by the blend of adhesive and repulsive components therein. Using immunohistochemical methods; we observed that the large extracellular matrix-protein, tenascin-R (Restrictin, J1-160-180, Janusin), associates preferentially with the parvalbumin-positive subpopulation of interneurones within the cerebral cortex. In situ-hybridization indicated that-tenascin-R-mRNA was expressed in a subpopulation of nerve cells distinct from that containing parvalbumin, suggesting that this protein's association with the latter is receptor mediated. These nerve cells thus modulate at a distance the composition of the extracellular matrix around parvalbumin-neurons.
Keywords:	Cerebral Cortex, Extracellular Matrix, Immunochemistry, Interneurons, Neurons, Parvalbumins, Tenascin, Animals, Rats
Source:	Journal of Neurocytology
ISSN:	0300-4864
Publisher:	Kluwer Academic Publishers
Volume:	30
Number:	4
Page Range:	293-301
Date:	1 January 2001
Official Publication:	https://doi.org/10.1023/A:1014452212067
PubMed:	View item in PubMed

Repository Staff Only: item control page