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| Item Type: | Article |
|---|---|
| Title: | Apical contacts stemming from incomplete delamination guide progenitor cell allocation through a dragging mechanism |
| Creators: |
Pulgar, Eduardo, Schwayer, Cornelia  ORCID: https://orcid.org/0000-0001-5130-2226, Guerrero, Néstor, López, Loreto, Márquez, Susana, Härtel, Steffen, Soto, Rodrigo, Heisenberg, Carl-Philipp and Concha, Miguel L.
|
| Abstract: | The developmental strategies used by progenitor cells to allow a safe journey from their induction place towards the site of terminal differentiation are still poorly understood. Here, we uncovered a mechanism of progenitor cell allocation that stems from an incomplete process of epithelial delamination that allows progenitors to coordinate their movement with adjacent extra- embryonic tissues. Progenitors of the zebrafish laterality organ originate from the superficial epithelial enveloping layer by an apical constriction process of cell delamination. During this process, progenitors retain long- lasting apical contacts that enable the epithelial layer to pull a subset of progenitors on their way to the vegetal pole. The remaining delaminated cells follow the movement of apically attached progenitors by a protrusion- dependent cell- cell contact mechanism, avoiding sequestration by the adjacent endoderm, ensuring their collective fate and allocation at the site of differentiation. Thus, we reveal that incomplete delamination serves as a cellular platform for coordinated tissue movements during development. |
| Keywords: | Cell Adhesion, Cell Communication, Cell Differentiation, Cell Lineage, Cell Movement, Developmental Gene Expression Regulation, Epithelial Cells, Genetically Modified Animals, Morphogenesis, Nonmammalian Embryo, Stem Cells, Time Factors, Animals, Zebrafish |
| Source: | eLife |
| ISSN: | 2050-084X |
| Publisher: | eLife Sciences Publications |
| Volume: | 10 |
| Page Range: | e66483 |
| Date: | 23 November 2021 |
| Official Publication: | https://doi.org/10.7554/elife.66483 |
| PubMed: | View item in PubMed |
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