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| Item Type: | Article |
|---|---|
| Title: | Ablation of Prdm16 and beige fat identity causes vascular remodeling and elevated blood pressure |
| Creators: |
Koenen, Mascha  ORCID: https://orcid.org/0000-0002-1024-4506, Becher, Tobias, Pagano, Giulia, Del Gaudio, Ilaria, Barrero, Jorge A., Montezano, Augusto C., Ruiz Ortiz, Jenelys, Lin, Zeran, Gómez-Banoy, Nicolás, Amblard, Rose, Schriever, Daniel, Kars, Meltem E., Rubinelli, Luisa, Halix, Sarah J., Huang Cao, Zhen Fang, Zeng, Xing, Butler, Scott D., Itan, Yuval, Touyz, Rhian M., Di Lorenzo, Annarita and Cohen, Paul
|
| Abstract: | Excess adiposity is a major risk factor for hypertension and heart disease. Brown fat is associated with protection from cardiovascular pathology, but whether this relationship is causal remains unknown. In this work, we investigate the role of mouse beige fat, as a model of human inducible brown fat, in adipocyte-vascular cross-talk. Using adipocyte-specific Prdm16 knockout mice with a loss of beige adipocyte identity, we discovered marked remodeling of perivascular adipose tissue, increased vascular reactivity, and elevated blood pressure. We show that the circulating enzyme QSOX1 is derepressed in Prdm16-deficient adipocytes, and deletion of Qsox1 in Prdm16 conditional knockout mice prevented vascular fibrosis and normalized vascular reactivity. These results demonstrate a key role for beige adipocytes in blood pressure regulation and identify QSOX1 as an important mediator of adipocyte-vascular cross-talk. |
| Keywords: | Adiposity, Beige Adipocytes, Beige Adipose Tissue, Blood Pressure, Brown Adipose Tissue, DNA-Binding Proteins, Fibrosis, Hypertension, Knockout Mice, Transcription Factors, Vascular Remodeling, Animals, Mice |
| Source: | Science |
| ISSN: | 0036-8075 |
| Publisher: | American Association for the Advancement of Science |
| Volume: | 391 |
| Number: | 6782 |
| Page Range: | 306-313 |
| Date: | 15 January 2026 |
| Additional Information: | Copyright © 2026 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. https://www.sciencemag.org/about/science-licenses-journal-article-reuse. This is an article distributed under the terms of the Science Journals Default License. |
| Official Publication: | https://doi.org/10.1126/science.ady8644 |
| External Fulltext: | View full text on external repository or document server |
| PubMed: | View item in PubMed |
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