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| Item Type: | Article |
|---|---|
| Title: | Sex-based differences in outcomes after transcatheter edge-to-edge repair for severe mitral regurgitation |
| Creators: |
Sauter, Reinhard J., Schupp, Tobias  ORCID: https://orcid.org/0000-0001-8171-7617, Sauter, Manuela, Sieburg, Tina, Britsch, Simone, Gregori, Serena, Alnaggar, Nada, Patzelt, Johannes, Behnes, Michael, Zhang, Yingying, Duerschmied, Daniel ORCID: https://orcid.org/0000-0001-5249-4012, Meyer-Zuern, Christine S., Magunia, Harry ORCID: https://orcid.org/0000-0001-9576-6399, Gawaz, Meinrad P., Geisler, Tobias, Akin, Ibrahim and Langer, Harald F.
|
| Abstract: | BACKGROUND: Whether differences in outcomes exist between men and women after transcatheter edge-to-edge repair is currently unknown. OBJECTIVES: This study investigated sex-based differences in outcomes after mitral transcatheter edge-to-edge repair (M-TEER) for severe mitral regurgitation (MR). METHODS: Patients undergoing M-TEER were included from May 2014 to October 2025. The prognostic impact of sex was investigated with regard to the primary endpoint all-cause mortality at 6 months. The secondary endpoints comprised the reduction of MR, rehospitalization for heart failure (HF) and functional capacity as assessed by the 6-minute walk test. RESULTS: Of the 293 patients enrolled in the study, 119 (40.6%) were women. Compared with men, women had a similar severity of MR independent of its etiology. The prevalence of coronary artery disease (81% vs 65%; P = 0.002), and the proportion of functional MR (47% vs 37%) were higher in males. The risk of all-cause mortality at 6 months did not significantly differ in males and females (22% vs 17%; P = 0.301; adjusted OR = 0.929; 95% CI: 0.474-1.822; P = 0.830), paralleled by comparable rates of HF-related rehospitalization (10% vs 13%; P = 0.576; adjusted OR = 1.151; 95% CI: 0.520-2.548; P = 0.729). By contrast, women demonstrated a significantly lower functional capacity at baseline (P = 0.001). Interestingly, at 6 months mean improvement of functional capacity was similar between male and female patients (P = 0.778). CONCLUSIONS: Women undergoing M-TEER presented at a more advanced age and with higher symptom burden than men, potentially reflecting sex-specific clinical trajectories and differing MR etiologies. However, midterm outcomes, including all-cause mortality and HF rehospitalization, were comparable between sexes. |
| Keywords: | Echocardiography, Gender, Mitral Regurgitation, Mitral Transcatheter Edge-to-Edge Repair, Sex |
| Source: | JACC: Advances |
| ISSN: | 2772-963X |
| Publisher: | Elsevier / American College of Cardiology |
| Page Range: | 103120 |
| Date: | 26 August 2026 |
| Official Publication: | https://doi.org/10.1016/j.jacadv.2026.103120 |
| PubMed: | View item in PubMed |
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