CXCR4-targeted molecular imaging in hematology and oncology

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Item Type:	Article
Title:	CXCR4-targeted molecular imaging in hematology and oncology
Creators:	Werner, Rudolf A., Buck, Andreas K., Haug, Alexander, Kraeber-Bodéré, Francoise, Lapa, Constantin, Schottelius, Margret, Serfling, Sebastian E., Higuchi, Takahiro, Bodet-Milin, Caroline, Raderer, Markus, Wegen, Simone, Pomper, Martin G., Deroose, Christophe M., Herrmann, Ken, Keller, Ulrich ORCID: https://orcid.org/0000-0002-8485-1958, Kobe, Carsten and Gotthardt, Martin
Abstract:	C-X-C motif chemokine receptor 4 (CXCR4) has emerged as a powerful imaging target in nuclear oncology. In this regard, the PET agent [68Ga]Ga-pentixafor is promising but still evolving. In this article, we provide an overview of potentially useful imaging applications for CXCR4-targeted imaging in hemato-oncology and guidance on scan interpretation by discussing diagnostic pitfalls. We also report on theranostic efforts and how the field has been expanded toward the imaging of solid tumors. As such, this review focuses on potential clinical integration of CXCR4-targeted molecular imaging across multiple disease entities, particularly in the field of hemato-oncology.
Keywords:	C-X-C Motif Chemokine Receptor 4, CXCR4, Chemokine Receptor, Imaging, PET, PET/CT, Theranostics, Hematology, Oncology
Source:	Journal of Nuclear Medicine
ISSN:	0161-5505
Publisher:	Society of Nuclear Medicine and Molecular Imaging
Date:	13 August 2026
Official Publication:	https://doi.org/10.2967/jnumed.126.272587
PubMed:	View item in PubMed

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