![[feed]](/style/images/feed-icon-14x14.png){kind=icon}
Tools
Tools
Preview |
PDF (Original Article)
- Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
3MB |
![[thumbnail of Supplementary Information]](https://edoc.mdc-berlin.de/style/images/fileicons/other.png) |
Other (Supplementary Information)
16MB |
| Item Type: | Article |
|---|---|
| Title: | B cell CD19 is transferred between immune cells in mice and humans |
| Creators: |
Ochs, Jasmin, Schweineberg, Pia, Thode, Jacqueline, Blenkle, Alica  ORCID: https://orcid.org/0000-0002-4641-1863, Husseini, Leila, Klein, Matthias, Bopp, Tobias ORCID: https://orcid.org/0000-0002-3232-8065, Schindler, Patrick, Paul, Friedemann ORCID: https://orcid.org/0000-0002-6378-0070 and Weber, Martin S. ORCID: https://orcid.org/0000-0001-8409-0389
|
| Abstract: | When immune cells interact, they frequently exchange membrane-bound antigens. Our evolving understanding of these processes challenges the cellular specificity of lineage markers and therapeutic monoclonal antibodies. By using mouse and human B-T cell co-cultures, we report that CD19, an assumingly exclusive B cell marker, is transferred via trogocytosis when B cells activate T cells. In a B cell-driven model of experimental autoimmune encephalomyelitis, CD19(+) T cells expand and show enhanced features of activation, differentiation, and encephalitogenic potential ex vivo. Additionally, co-transfer of CD19 and functional IgM from B cells results in the gain of B cell function by T cells. In patients with chronic central nervous system (CNS) demyelination, CD19(+) T cells display a pro-inflammatory phenotype and are concomitantly depleted by inebilizumab, an approved anti-CD19 antibody, which raises important considerations for the therapeutic use of monoclonal antibodies overall. Finally, we report that myeloid cells acquire CD19 and functional IgM after phagocytosis of apoptotic B cells and thereby gain functional B cell properties. These findings highlight the commonness of membrane and antigen-transfer between cells, resulting in transmission of cellular function. |
| Keywords: | B-Lymphocytes, CD19 Antigens, Coculture Techniques, Experimental Autoimmune Encephalomyelitis, Immunoglobulin M, Inbred C57BL Mice, Lymphocyte Activation, T-Lymphocytes, Trogocytosis, Animals, Mice |
| Source: | Nature Communications |
| ISSN: | 2041-1723 |
| Publisher: | Nature Publishing Group |
| Volume: | 17 |
| Number: | 1 |
| Page Range: | 7588 |
| Date: | 29 July 2026 |
| Official Publication: | https://doi.org/10.1038/s41467-026-75534-3 |
| PubMed: | View item in PubMed |
| Related to: |
Repository Staff Only: item control page
