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| Item Type: | Review |
|---|---|
| Title: | Metabolic control of RNA splicing by polyamines |
| Creators: |
Hofer, Sebastian J.  ORCID: https://orcid.org/0000-0002-0756-0014, Alsaleh, Ghada ORCID: https://orcid.org/0000-0002-4211-3420 and Simon, Anna Katharina ORCID: https://orcid.org/0000-0002-4077-7995
|
| Abstract: | Polyamines are ancient metabolites that support growth, translation, and autophagy. Zabala-Letona et al. reveal a new mode of action—‘metabolic shielding’—in which polyamines protect phosphorylation motifs in spliceosomal factors. This work links polyamines, for the first time, to alternative splicing, raising new questions for cancer, aging, and beyond. |
| Source: | Trends in Biochemical Sciences |
| ISSN: | 0968-0004 |
| Publisher: | Elsevier / Cell Press |
| Date: | 26 June 2026 |
| Official Publication: | https://doi.org/10.1016/j.tibs.2026.06.001 |
| PubMed: | View item in PubMed |
| Related to: |
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