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| Item Type: | Dataset |
|---|---|
| Title: | RIF1 acts as a gatekeeper of B cell identity during late differentiation |
| Creators Name: | Di Virgilio, Michela |
| Abstract: | RIF1 is a multifunctional protein that promotes immunoglobulin (Ig) isotype diversification. Whether RIF1 plays additional roles in adaptive immunity is unknown. In this study, we observed an upregulation of RIF1 expression following mature B cell activation, while its deficiency led to a deregulated expression profile enriched in genes typically expressed in B cell progenitors and plasma cells (PC). RIF1 ablation resulted in increased plasmablast formation ex vivo and enhanced terminal differentiation into PC upon immunization. Therefore, RIF1 serves as a cell identity gatekeeper during late B cell differentiation, providing an additional layer of control in the establishment of humoral immunity. |
| Source: | Gene Expression Omnibus (GEO) |
| Publisher: | National Center for Biotechnology Information (NCBI) |
| Date: | 8 February 2024 |
| Official Publication: | https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE237560 |
| Related to: |
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