Vaskulitis im Kontext des Alterns: Herausforderungen für Diagnose und Management [Vasculitis in the context of aging: challenges for diagnosis and management]

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Item Type:	Article
Title:	Vaskulitis im Kontext des Alterns: Herausforderungen für Diagnose und Management [Vasculitis in the context of aging: challenges for diagnosis and management]
Creators Name:	Mestekemper, A.N. and Schreiber, A.
Abstract:	Increasing life expectancy is leading to a growing number of older patients with vasculitides. Giant cell arteritis and ANCA-associated vasculitides are particularly prevalent in advanced age and are characterized by multimorbidity, age-related organ vulnerability, and altered pharmacodynamics. Key pathophysiological mechanisms include immunosenescence and inflammaging, which, through immune dysregulation, chronic inflammation, and endothelial dysfunct ion, promote the onset and progression of autoimmune-mediated vascular inflammat ion. Management therefore requires an individualized, interdisciplinary approach that balances efficacy and risk of adverse events. Steroid-sparing strategies, supportive measures, and the integration of geriatric concepts are crucial to preserve functionality and quality of life in older adults. Future studies should specifically include elderly cohorts.
Keywords:	Vasculitis, Immunosenescence, Inflammaging, ANCA-Associated Vasculitis, Giant Cell Arteriitis
Source:	Nieren- und Hochdruckkrankheiten
ISSN:	0300-5224
Publisher:	Dustri
Volume:	54
Number:	12
Page Range:	466-473
Number of Pages:	8
Date:	December 2025
Official Publication:	https://doi.org/10.5414/NHX02492

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