![[feed]](/style/images/feed-icon-14x14.png){kind=icon}
Tools
Tools
Preview |
PDF (Original Article)
- Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
7MB |
![[thumbnail of Supplementary Information]](https://edoc.mdc-berlin.de/style/images/fileicons/other.png) |
Other (Supplementary Information)
1MB |
| Item Type: | Article |
|---|---|
| Title: | Microglia protein profiles in CSF across Alzheimer's disease clinical stages |
| Creators: |
Blujdea, Elena-Raluca  ORCID: https://orcid.org/0009-0001-7305-2122, van Bokhoven, Pieter, Martino-Adami, Pamela V. ORCID: https://orcid.org/0000-0002-1067-1495, Marshe, Victoria S., Vromen, Ellen M., Hok-A-Hin, Yanaika S. ORCID: https://orcid.org/0000-0001-9713-116X, Boiten, Walter A., Irwin, David J. ORCID: https://orcid.org/0000-0002-5599-5098, Chen-Plotkin, Alice S. ORCID: https://orcid.org/0000-0002-3387-2038, Lemstra, Afina W., Pijnenburg, Yolande, van der Flier, Wiesje M. ORCID: https://orcid.org/0000-0001-8766-6224, Peters, Oliver ORCID: https://orcid.org/0000-0003-0568-2998, Hellmann-Regen, Julian ORCID: https://orcid.org/0000-0003-0411-9204, Priller, Josef ORCID: https://orcid.org/0000-0001-7596-0979, Schneider, Anja ORCID: https://orcid.org/0000-0001-9540-8700, Wiltfang, Jens ORCID: https://orcid.org/0000-0003-1492-5330, Jessen, Frank, Düzel, Emrah, Buerger, Katharina, Perneczky, Robert ORCID: https://orcid.org/0000-0003-1981-7435, Teipel, Stefan, Laske, Christoph, Brosseron, Frederic ORCID: https://orcid.org/0000-0003-3137-7516, Del Campo, Marta ORCID: https://orcid.org/0000-0003-2808-3699, Wijdeven, Ruud, Visser, Pieter-Jelle ORCID: https://orcid.org/0000-0001-8008-9727, Tijms, Betty M. ORCID: https://orcid.org/0000-0002-2612-1797, De Jager, Philip L. ORCID: https://orcid.org/0000-0002-8057-2505, Ramirez, Alfredo ORCID: https://orcid.org/0000-0003-4991-763X, Teunissen, Charlotte E. ORCID: https://orcid.org/0000-0002-4061-0837 and Vermunt, Lisa ORCID: https://orcid.org/0000-0001-7420-6384
|
| Abstract: | Microglia are implicated in the progression of Alzheimer’s disease (AD) pathology from its earliest stages, suggesting that cerebrospinal fluid (CSF) microglia profiling across clinical AD stages can aid in treatment development and monitoring. We analyzed two CSF cohorts (n = 834) that span from unimpaired controls to preclinical and dementia AD stages, identifying 109 dysregulated microglia-related proteins. Enrichment analyses revealed innate immune processes and cellular recruitment in preclinical AD, whereas AD dementia revealed adaptive immunity and macrophage responses. Next, we aligned the in vivo microglia protein profiles with ex vivo-derived microglial transcriptomic signatures, such as disease-associated microglia phenotypes. Transcriptomic signatures were not specific to either clinical stage but spanned both. We classified an 18-protein panel highlighting distinct changes between the preclinical and dementia stages. Our findings underscore the potential of microglia-based biomarker research for AD staging, offering insights into microglia dynamics in clinical AD stages and how transcriptomic signatures translate to proteomic profiles. |
| Keywords: | Alzheimer Disease, Biomarkers, Disease Progression, Microglia, Proteomics, Transcriptome |
| Source: | Nature Aging |
| ISSN: | 2662-8465 |
| Publisher: | Springer Nature |
| Volume: | 6 |
| Number: | 3 |
| Page Range: | 520-533 |
| Date: | March 2026 |
| Official Publication: | https://doi.org/10.1038/s43587-026-01088-0 |
| PubMed: | View item in PubMed |
| Related to: |
Repository Staff Only: item control page
