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Nanoscale dynamics of enhancer-promoter interactions during exit from pluripotency

Item Type:Dataset
Title:Nanoscale dynamics of enhancer-promoter interactions during exit from pluripotency
Creators: Stumberger, Gabriela ORCID logoORCID: https://orcid.org/0000-0002-5630-0032, Hörl, David ORCID logoORCID: https://orcid.org/0000-0003-1710-1708, Tsouraki, Dimitra ORCID logoORCID: https://orcid.org/0009-0006-1428-6718, Steinek, Clemens ORCID logoORCID: https://orcid.org/0000-0003-3590-2103, Oudelaar, Aukje Marieke ORCID logoORCID: https://orcid.org/0000-0002-4016-6158, Leonhardt, Heinrich ORCID logoORCID: https://orcid.org/0000-0002-5086-6449 and Harz, Hartmann ORCID logoORCID: https://orcid.org/0000-0003-1218-2107
Abstract:This Zenodo repository contains data generated for our manuscript. It contains: fig1.csv: Color/shift corrected, pairwise enhancer-promoter coordinates [µm] and distances [µm], in naive and primed mouse embryonic stem cells (mESCs), measured with a spinning disk confocal microscope. Related to Fig 1. fig2.csv: Multiway enhancer-promoter coordinates [µm] and distances for promoters with all their enhnacers [µm], in naive and primed mESCs, measured with a STED mircoscope. Related to Fig 2 D-G and Supplementary Fig S9. fig3.csv: Coordinates [µm] and distances between the promoter [µm] (Nanog or Dppa3), its closest ehnacer and closest intron RNA, in naive mESCs, measured with a STED microscope in confocal mode. Related to Fig 3 and Supplementary Fig S10 C. figS10.csv: Coordinates [µm] and distances between the Nanog promoter [µm], its 3 enhancers (-5, -45, +60) and closest intron RNA, in naive mESCs, measured with a STED microscope. Related to Supplementary Fig S10 D. region_coordinates_mm9.bed: Target names (promoters and enhnacers by the distance from their promoter) and the coordinates of the probed genomic region in mm9.
Source:Zenodo
Publisher:CERN
Date:14 September 2025
Official Publication:https://doi.org/10.5281/zenodo.17115347

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