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A kinetics-based model of hematopoiesis reveals extrinsic regulation of skewed lineage output from stem cells - data repository

Item Type:Dataset
Title:A kinetics-based model of hematopoiesis reveals extrinsic regulation of skewed lineage output from stem cells - data repository
Creators: Grünschläger, Florian ORCID logoORCID: https://orcid.org/0000-0003-0021-6912, Rodriguez-Correa, Esther, Nizharadze, Tamar, Sedlmeier, Anastasia ORCID logoORCID: https://orcid.org/0009-0002-0418-2131, Hübschmann, Daniel ORCID logoORCID: https://orcid.org/0000-0002-6041-7049 and Haas, Simon ORCID logoORCID: https://orcid.org/0000-0001-9227-2051
Abstract:Single-cell RNA sequencing data from five single-HSC-derived murine hematopoietic systems, as well as two polyclonal controls. The resulting clonally-resolved hematopoietic bone marrow atlas (scBM_atlas.rds) consists of 76,863 high-quality cells and covers all major hematopoietic cell types, including differentiation tracks (slingshot.rds) from the most immature HSCs to all lineage-committed progenitors (HSPCs.rds) and their continued maturation into blood and immune cells.
Source:Zenodo
Publisher:CERN
Date:January 2025
Official Publication:https://doi.org/10.5281/zenodo.14497706
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