B cell and aquaporin-4 antibody relationships with neuromyelitis optica spectrum disorder activity

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Item Type:	Article
Title:	B cell and aquaporin-4 antibody relationships with neuromyelitis optica spectrum disorder activity
Creators Name:	Bennett, J.L., Pittock, S.J., Paul, F., Kim, H.J., Irani, S.R., O'Connor, K.C., Patterson, K.R., Smith, M.A., Gunsior, M., Mittereder, N., Rees, W.A., Cimbora, D. and Cree, B.A.C.
Abstract:	This post hoc analysis of the randomized, placebo-controlled N-MOmentum study (NCT02200770) of inebilizumab in neuromyelitis optica spectrum disorder (NMOSD) evaluated relationships between circulating B-cell subsets and aquaporin-4 immunoglobulin G (AQP4-lgG) titers and attacks. Among participants receiving placebo, CD20(+) and CD27(+) B-cell counts were modestly increased from the pre-attack visit to attack; plasmablast/plasma cell gene signature was increased from baseline to the pre-attack visit (p = 0.016) and from baseline to attack (p = 0.009). With inebilizumab treatment, B-cell subset counts decreased and did not increase with attacks. No difference in change of AQP4-IgG titers from baseline to time of attack was observed.
Keywords:	Aquaporin 4, Autoantibodies, B-Lymphocyte Subsets, B-Lymphocytes, Humanized Monoclonal Antibodies, Immunoglobulin G, Neuromyelitis Optica
Source:	Annals of Clinical and Translational Neurology
ISSN:	2328-9503
Publisher:	Wiley
Volume:	11
Number:	10
Page Range:	2792-2798
Date:	October 2024
Official Publication:	https://doi.org/10.1002/acn3.52171
PubMed:	View item in PubMed

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