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| Item Type: | Article |
|---|---|
| Title: | B cell and aquaporin-4 antibody relationships with neuromyelitis optica spectrum disorder activity |
| Creators Name: | Bennett, J.L., Pittock, S.J., Paul, F., Kim, H.J., Irani, S.R., O'Connor, K.C., Patterson, K.R., Smith, M.A., Gunsior, M., Mittereder, N., Rees, W.A., Cimbora, D. and Cree, B.A.C. |
| Abstract: | This post hoc analysis of the randomized, placebo-controlled N-MOmentum study (NCT02200770) of inebilizumab in neuromyelitis optica spectrum disorder (NMOSD) evaluated relationships between circulating B-cell subsets and aquaporin-4 immunoglobulin G (AQP4-lgG) titers and attacks. Among participants receiving placebo, CD20(+) and CD27(+) B-cell counts were modestly increased from the pre-attack visit to attack; plasmablast/plasma cell gene signature was increased from baseline to the pre-attack visit (p = 0.016) and from baseline to attack (p = 0.009). With inebilizumab treatment, B-cell subset counts decreased and did not increase with attacks. No difference in change of AQP4-IgG titers from baseline to time of attack was observed. |
| Keywords: | Aquaporin 4, Autoantibodies, B-Lymphocyte Subsets, B-Lymphocytes, Humanized Monoclonal Antibodies, Immunoglobulin G, Neuromyelitis Optica |
| Source: | Annals of Clinical and Translational Neurology |
| ISSN: | 2328-9503 |
| Publisher: | Wiley |
| Volume: | 11 |
| Number: | 10 |
| Page Range: | 2792-2798 |
| Date: | October 2024 |
| Official Publication: | https://doi.org/10.1002/acn3.52171 |
| PubMed: | View item in PubMed |
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