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| Item Type: | Article |
|---|---|
| Title: | SARS-CoV-2-specific antibody (Ab) levels and the kinetic of ab decline determine Ab persistence over 1 year |
| Creators Name: | Garner-Spitzer, E., Wagner, A., Kundi, M., Stockinger, H., Ohradanova-Repic, A., Gebetsberger, L., Schoetta, A.M., Gudipati, V., Huppa, J.B., Kunert, R., Mayrhofer, P., Kreil, T.R., Farcet, M.R., Hoeltl, E. and Wiedermann, U. |
| Abstract: | In a SARS-CoV-2 seroprevalence study conducted with 1,655 working adults in spring of 2020, 12 of the subjects presented with positive neutralization test (NT) titers (>1:10). They were here followed up for 1 year to assess their Ab persistence. We report that 7/12 individuals (58%) had NT_50 titers ≥1:50 and S1-specific IgG ≥50 BAU/ml 1 year after mild COVID-19 infection. S1-specific IgG were retained until a year when these levels were at least >60 BAU/ml at 3 months post-infection. For both the initial fast and subsequent slow decline phase of Abs, we observed a significant correlation between NT_50 titers and S1-specific IgG and thus propose S1-IgG of 60 BAU/ml 3 months post-infection as a potential threshold to predict neutralizing Ab persistence for 1 year. NT_50 titers and S1-specific IgG also correlated with circulating S1-specific memory B-cells. SARS-CoV-2-specific Ab levels after primary mRNA vaccination in healthy controls were higher (Geometric Mean Concentration [GMC] 3158 BAU/ml [CI 2592 to 3848]) than after mild COVID-19 infection (GMC 82 BAU/ml [CI 48 to 139]), but showed a stronger fold-decline within 5-6 months (0.20-fold, to GMC 619 BAU/ml [CI 479 to 801] vs. 0.56-fold, to GMC 46 BAU/ml [CI 26 to 82]). Of particular interest, the decline of both infection- and vaccine-induced Abs correlated with body mass index. Our data contribute to describe decline and persistence of SARS-CoV-2-specific Abs after infection and vaccination, yet the relevance of the maintained Ab levels for protection against infection and/or disease depends on the so far undefined correlate of protection. |
| Keywords: | SARS-CoV-2, Infection, Neutralizing Abs, Antibody Kinetics, Vaccination, Persistence |
| Source: | Frontiers in Medicine |
| ISSN: | 2296-858X |
| Publisher: | Frontiers Media SA |
| Volume: | 9 |
| Page Range: | 822316 |
| Date: | 15 February 2022 |
| Official Publication: | https://doi.org/10.3389/fmed.2022.822316 |
| PubMed: | View item in PubMed |
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