T-cell antigen recognition: catch-as-catch-can or catch-22?

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Item Type:	Editorial
Title:	T-cell antigen recognition: catch-as-catch-can or catch-22?
Creators Name:	Huppa, J.B. and Schütz, G.J.
Abstract:	T-cell antigen recognition is invariably affected by tensile forces as they are exerted on T-cell antigen receptors (TCRs) transiently binding antigenic peptide/MHC complexes. In this issue of The EMBO Journal, Pettmann and colleagues promote the concept that forces reduce the lifetime of more stable stimulatory TCR-pMHC interactions to a larger extent than that of less stable non-stimulatory TCR-pMHC interactions. The authors argue that forces impede rather than boost T-cell antigen discrimination, which is promoted by force-shielding within the immunological synapse through cell adhesion via CD2/CD58 and LFA-1/ICAM-1.
Keywords:	T-Cell Antigen Receptors, T-Lymphocytes
Source:	EMBO Journal
ISSN:	0261-4189
Publisher:	EMBO Press / Wiley
Volume:	42
Number:	7
Page Range:	e113507
Date:	3 April 2023
Official Publication:	https://doi.org/10.15252/embj.2023113507
PubMed:	View item in PubMed

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