3D spheroid and organoid models to study neuroinfection of RNA viruses

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Item Type:	Article
Title:	3D spheroid and organoid models to study neuroinfection of RNA viruses
Creators Name:	Dos Reis, V.P., Cirksena, K., Rybak-Wolf, A., Seeger, B., Herker, E. and Gerold, G.
Abstract:	Three-dimensional culture models of the brain enable the study of neuroinfection in the context of a complex interconnected cell matrix. Depending on the differentiation status of the neural cells, two models exist: 3D spheroids also called neurospheres and cerebral organoids. Here, we describe the preparation of 3D spheroids and cerebral organoids and give an outlook on their usage to study Rift Valley fever virus and other neurotropic viruses.
Keywords:	3D Spheroid, Neurosphere, Cerebral Organoid, Neurotropic Virus, Neuroinfection, Neural Progenitor Cells, Induced Pluripotent Stem Cells, Animals
Source:	Methods in Molecular Biology
Series Name:	Methods in Molecular Biology
Title of Book:	Rift valley fever virus : methods and protocols
ISSN:	1064-3745
ISBN:	978-1-0716-3925-2
Publisher:	Springer / Humana Press
Volume:	2824
Page Range:	409-424
Date:	August 2024
Official Publication:	https://doi.org/10.1007/978-1-0716-3926-9_26
PubMed:	View item in PubMed

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