Fraternal twins at work: Structures of PLD3/4 reveal mechanism for lysosomal nucleic acid breakdown

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Item Type:	Editorial
Title:	Fraternal twins at work: Structures of PLD3/4 reveal mechanism for lysosomal nucleic acid breakdown
Creators Name:	Daumke, O. and Damme, M.
Abstract:	Phospholipase D (PLD) family proteins degrade phospholipids and nucleic acids. In the current issue of Structure, Yuan et al. report crystal structures of lysosomal PLD3 and PLD4 with and without a single-stranded DNA substrate. Their manuscript reveals a catalytic ping-pong mechanism and explains how disease-associated mutations compromise PLD3/4 function.
Keywords:	Lysosomes, Phospholipase D
Source:	Structure
ISSN:	0969-2126
Publisher:	Cell Press
Volume:	32
Number:	6
Page Range:	645-647
Date:	6 June 2024
Official Publication:	https://doi.org/10.1016/j.str.2024.05.002
PubMed:	View item in PubMed

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