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IL-33 controls IL-22-dependent antibacterial defense by modulating the microbiota

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Item Type:Article
Title:IL-33 controls IL-22-dependent antibacterial defense by modulating the microbiota
Creators Name:Röwekamp, I., Maschirow, L., Rabes, A., Fiocca Vernengo, F., Hamann, L., Heinz, G.A., Mashreghi, M.F., Caesar, S., Milek, M., Fagundes Fonseca, A.C., Wienhold, S.M., Nouailles, G., Yao, L., Mousavi, S., Bruder, D., Boehme, J.D., Puzianowska-Kuznicka, M., Beule, D., Witzenrath, M., Löhning, M., Klose, C.S.N., Heimesaat, M.M., Diefenbach, A. and Opitz, B.
Abstract:IL-22 plays a critical role in defending against mucosal infections, but how IL-22 production is regulated is incompletely understood. Here, we show that mice lacking IL-33 or its receptor ST2 (IL-1RL1) were more resistant to Streptococcus pneumoniae lung infection than wild-type animals and that single-nucleotide polymorphisms in IL33 and IL1RL1 were associated with pneumococcal pneumonia in humans. The effect of IL-33 on S. pneumoniae infection was mediated by negative regulation of IL-22 production in innate lymphoid cells (ILCs) but independent of ILC2s as well as IL-4 and IL-13 signaling. Moreover, IL-33's influence on IL-22-dependent antibacterial defense was dependent on housing conditions of the mice and mediated by IL-33's modulatory effect on the gut microbiota. Collectively, we provide insight into the bidirectional crosstalk between the innate immune system and the microbiota. We conclude that both genetic and environmental factors influence the gut microbiota, thereby impacting the efficacy of antibacterial immune defense and susceptibility to pneumonia.
Keywords:Pneumonia, Streptococcus Pneumoniae, Microbiota, IL-33, IL-22, Animals, Mice
Source:Proceedings of the National Academy of Sciences of the United States of America
ISSN:0027-8424
Publisher:National Academy of Sciences
Volume:121
Number:22
Page Range:e2310864121
Date:28 May 2024
Official Publication:https://doi.org/10.1073/pnas.2310864121
PubMed:View item in PubMed

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