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Oligonucleotide library screening for identification of virus-specific T-cell receptors

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Item Type:Article
Title:Oligonucleotide library screening for identification of virus-specific T-cell receptors
Creators Name:Welters, M.L., Stadler, S., Anastasopoulou, V., Bullinger, L., Leisegang, M., Kammertöns, T., Welters, C. and Hansmann, L.
Abstract:We demonstrate an optimized oligonucleotide library-based approach for the identification of virus-reactive T-cell receptors using Epstein-Barr virus as an example. HEK293T served as antigen-presenting cells and were co-cultured with human T cells that were transduced with T-cell receptors in question. T-cell activation was detected by CD137 expression.
Keywords:Epstein-Barr Virus, Oligonucleotide Library, Target Epitope Screening, T-Cell Immunology, TCR Antigen Identification
Source:European Journal of Immunology
ISSN:0014-2980
Publisher:Wiley
Volume:56
Number:6
Page Range:e2350908
Date:June 2024
Official Publication:https://doi.org/10.1002/eji.202350908
PubMed:View item in PubMed

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