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| Item Type: | Article |
|---|---|
| Title: | Mortality of neuromyelitis optica spectrum disorder patients in an Argentinean population: a study from the RelevarEM registry |
| Creators: |
Carnero Contentti, E.  ORCID: https://orcid.org/0000-0001-7435-5726, Lopez, P.A. ORCID: https://orcid.org/0000-0002-7705-095X, Pettinicchi, J.P., Criniti, J., Pappolla, A., Miguez, J., Cristiano, E., Patrucco, L., Liwacki, S., Tkachuk, V., Balbuena, M.E., Vrech, C., Deri, N., Correale, J., Marrodan, M. ORCID: https://orcid.org/0000-0002-4142-8375, Ysrraelit, M.C., Leguizamon, F., Luetic, G. ORCID: https://orcid.org/0000-0002-5716-6082, Menichini, M.L., Tavolini, D., Mainella, C., Zanga, G., Burgos, M., Hryb, J., Barboza, A., Lazaro, L., Alonso, R. ORCID: https://orcid.org/0000-0001-9955-8343, Fernández Liguori, N., Nadur, D., Alonso Serena, M., Caride, A., Paul, F. ORCID: https://orcid.org/0000-0002-6378-0070 and Rojas, J.I.
|
| Abstract: | We aimed to evaluate mortality and causes of death among Argentinean neuromyelitis optica spectrum disorder (NMOSD) patients and identify predictors of death. Retrospective study included 158 NMOSD patients and 11 (7%) patients died after 11 years of follow-up for a total exposure time of 53,345 days with an overall incidence density of 2.06 × 10.000 patients/day (95% CI 1.75-2.68). Extensive cervical myelitis with respiratory failure (45%) was the most frequent cause of death. Older age (HR = 2.05, p = 0.002) and higher disability score (HR = 2.30, p < 0.001) at disease onset were independent predictors of death. We found an 11-year mortality rate of 7% in Argentinean NMOSD patients. |
| Keywords: | Neuromyelitis Optica (NMO), Mortality, Latin America, Prognosis, Relapses |
| Source: | Multiple Sclerosis Journal Experimental Translational and Clinical |
| ISSN: | 2055-2173 |
| Publisher: | Sage Publications |
| Volume: | 9 |
| Number: | 4 |
| Page Range: | 20552173231205444 |
| Date: | 17 October 2023 |
| Official Publication: | https://doi.org/10.1177/20552173231205444 |
| PubMed: | View item in PubMed |
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