Immune cell subpopulations and serum neurofilament light chain are associated with increased risk of disease worsening in multiple sclerosis

Tools

Preview	PDF (Original Article) - Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader 3MB
	Other (Supplementary Data) 190kB

Item Type:	Article
Title:	Immune cell subpopulations and serum neurofilament light chain are associated with increased risk of disease worsening in multiple sclerosis
Creators Name:	Brune-Ingebretsen, S., Høgestøl, E.A., de Rosbo, N.K., Berg-Hansen, P., Brunborg, C., Blennow, K., Zetterberg, H., Paul, F., Uccelli, A., Villoslada, P., Harbo, H.F and Berge, T.
Abstract:	Changes is lymphocyte subpopulations in peripheral blood have been proposed as biomarkers for evaluation of disease activity in multiple sclerosis (MS). Serum neurofilament light chain (sNfL) is a biomarker reflecting neuro-axonal injury in MS that could be used to monitor disease activity, response to drugs and to prognosticate disease course. Here we show a moderate correlation between sNfL and lymphocyte cell subpopulations, and our data furthermore suggest that sNfL and specific immune cell subpopulations together could predict future disease worsening in MS.
Keywords:	Multiple Sclerosis, Serum Neurofilament Light Chain, Immune Cell Subset Frequencies, Biomarkers, Disease Worsening
Source:	Journal of Neuroimmunology
ISSN:	0165-5728
Publisher:	Elsevier
Volume:	382
Page Range:	578175
Date:	15 September 2023
Official Publication:	https://doi.org/10.1016/j.jneuroim.2023.578175
PubMed:	View item in PubMed

Repository Staff Only: item control page

Download Statistics

Downloads

Downloads per month over past year