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| Item Type: | Article |
|---|---|
| Title: | Frequency of new asymptomatic MRI lesions during attacks and follow-up of patients with NMOSD in a real-world setting |
| Creators: |
Carnero Contentti, E.  ORCID: https://orcid.org/0000-0001-7435-5726, Lopez, P.A., Tkachuk, V., Vrech, C., Zarate, M.A., Correale, J., Deri, N., Luetic, G. ORCID: https://orcid.org/0000-0002-5716-6082, Marrodan, M. ORCID: https://orcid.org/0000-0002-4142-8375, Pagani Cassara, F., Tavolini, D., Ysrraelit, M.C., Balbuena, M.E., Hryb, J., Chiganer, E., Leguizamon, F., Knorre, E., Zanga, G., Pestchanker, C. ORCID: https://orcid.org/0000-0002-5932-0215, Barboza, A., Nadur, D., Cristiano, E., Patrucco, L., Alonso, R. ORCID: https://orcid.org/0000-0001-9955-8343, Alonso Serena, M., Paul, F. ORCID: https://orcid.org/0000-0002-6378-0070 and Rojas, J.I.
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| Abstract: | BACKGROUND: We aimed to assess the frequency of new asymptomatic lesions on brain and spinal imaging (magnetic resonance imaging (MRI)) and their association with subsequent relapses in a large cohort of neuromyelitis optica spectrum disorder (NMOSD) patients in Argentina. METHODS: We retrospectively reviewed 675 MRI (225 performed during an attack and 450 during the relapse-free period (performed at least 3 months from the last attack)) of NMOSD patients who had at least 2 years of clinical and MRI follow-up since disease onset. Kaplan-Meier (KM) curves were used for depicting time from remission MRI to subsequent relapse. RESULTS: We included 135 NMOSD patients (64.4% were aquaporin-4-immunoglobulin G (AQP4-IgG)-positive). We found that 26 (19.26%) and 66 (48.88%) of patients experienced at least one new asymptomatic MRI lesion during both the relapse-free period and attacks, respectively. The most frequent asymptomatic MRI lesions were optic nerves followed by short-segment myelitis during the relapse-free period and attacks. KM curves did not show differences in the time taken to develop a new relapse. CONCLUSION: Our findings showed that new asymptomatic lesions are relatively frequent. However, the presence of new asymptomatic MRI lesions during the relapse-free period and at relapses was not associated with a shorter time to developing subsequent relapses. |
| Keywords: | Aquaporin 4, Autoantibodies, Brain, Follow-Up Studies, Magnetic Resonance Imaging, Neuromyelitis Optica, Retrospective Studies |
| Source: | Multiple Sclerosis Journal |
| ISSN: | 1352-4585 |
| Publisher: | Sage Publications |
| Volume: | 29 |
| Number: | 10 |
| Page Range: | 1240-1249 |
| Date: | September 2023 |
| Official Publication: | https://doi.org/10.1177/13524585231187120 |
| PubMed: | View item in PubMed |
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