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Many kinases for controlling the water channel aquaporin‐2

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Item Type:Review
Title:Many kinases for controlling the water channel aquaporin‐2
Creators Name:Kharin, A. and Klussmann, E.
Abstract:Aquaporin-2 (AQP2) is a member of the aquaporin water channel family. In the kidney, AQP2 is expressed in collecting duct principal cells where it facilitates water reabsorption in response to antidiuretic hormone (arginine vasopressin, AVP). AVP induces the redistribution of AQP2 from intracellular vesicles and its incorporation into the plasma membrane. The plasma membrane insertion of AQP2 represents the crucial step in AVP-mediated water reabsorption. Dysregulation of the system preventing the AQP2 plasma membrane insertion causes diabetes insipidus (DI), a disease characterised by an impaired urine concentrating ability and polydipsia. There is no satisfactory treatment of DI available. This review discusses kinases that control the localisation of AQP2 and points out potential kinase-directed targets for the treatment of DI.
Keywords:AKAP, AQP2, AURKA, cAMP Compartment, CDK18, p38 MAPK, PKA, Animals
Source:Journal of Physiology
ISSN:0022-3751
Publisher:Wiley
Volume:602
Number:13
Page Range:3025-3039
Date:1 July 2023
Official Publication:https://doi.org/10.1113/JP284100
PubMed:View item in PubMed

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