Alternatives to animal testing in basic and preclinical research of atopic dermatitis

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Item Type:	Review
Title:	Alternatives to animal testing in basic and preclinical research of atopic dermatitis
Creators Name:	Löwa, A., Jevtić, M., Gorreja, F. and Hedtrich, S.
Abstract:	Atopic dermatitis (AD) is a chronic inflammatory skin disease of increasing prevalence, especially in industrialized countries. Roughly 25% of the children and 1%-3% of adults are affected. Although significant progress has been made in the understanding of the pathogenesis of AD, many aspects remain poorly understood. Moreover, there is a pressing need for improved therapeutic options. Studies to elucidate the pathophysiological pathways of AD and to identify novel therapeutic targets over the last few decades have been conducted almost exclusively in animal models. However, in vitro approaches such as 3D skin disease models have recently emerged due to an increasing awareness of distinct interspecies-related differences that hamper the effective translation of results from animal models to humans. In addition, there is growing political and social pressure to develop alternatives to animal models according to the 3Rs principle (reduction, refinement and replacement of animal models).
Keywords:	3R Approach, Atopic Dermatitis, Preclinical Dermatology, Skin Equivalents, Skin Model, Animals
Source:	Experimental Dermatology
ISSN:	0906-6705
Publisher:	Blackwell Munskgaard
Volume:	27
Number:	5
Page Range:	476-483
Date:	May 2018
Official Publication:	https://doi.org/10.1111/exd.13498

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