C. elegans gene regulatory alleles and reporter bashing studies

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Item Type:	Article
Title:	C. elegans gene regulatory alleles and reporter bashing studies
Creators Name:	Froehlich, J.J. and Rajewsky, N.
Abstract:	Gene regulation has been studied in C. elegans for over 30 years. In this analysis of 102 publications, we find that most transcriptional cis-regulatory elements are located within 5,000 bp of the transcription start site. Over 75% of studies conclude that transcriptional elements and 5'UTRs activate-, while 3'UTRs repress gene expression. While gene regulatory mutations make up less than 0.8% of alleles in forward genetics screens, recent CRISPR-Cas approaches are increasing the number of tested mutations. This work provides a resource of known gene regulatory sequences in C.elegans.
Keywords:	Animals, Caenorhabditis elegans
Source:	microPublication Biology
ISSN:	2578-9430
Publisher:	Caltech Library
Volume:	2023
Date:	20 January 2023
Official Publication:	https://doi.org/10.17912/micropub.biology.000709
PubMed:	View item in PubMed

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