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| Item Type: | Article |
|---|---|
| Title: | C. elegans gene regulatory alleles and reporter bashing studies |
| Creators Name: | Froehlich, J.J. and Rajewsky, N. |
| Abstract: | Gene regulation has been studied in C. elegans for over 30 years. In this analysis of 102 publications, we find that most transcriptional cis-regulatory elements are located within 5,000 bp of the transcription start site. Over 75% of studies conclude that transcriptional elements and 5'UTRs activate-, while 3'UTRs repress gene expression. While gene regulatory mutations make up less than 0.8% of alleles in forward genetics screens, recent CRISPR-Cas approaches are increasing the number of tested mutations. This work provides a resource of known gene regulatory sequences in C.elegans. |
| Keywords: | Animals, Caenorhabditis elegans |
| Source: | microPublication Biology |
| ISSN: | 2578-9430 |
| Publisher: | Caltech Library |
| Volume: | 2023 |
| Date: | 20 January 2023 |
| Official Publication: | https://doi.org/10.17912/micropub.biology.000709 |
| PubMed: | View item in PubMed |
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