Neuroophthalmologische Präsentation der Retrobulbärneuritis im Rahmen der Myelin-Oligodendrozyten-Glykoprotein-Antikörper-assoziierten Erkrankung [Neuro-ophthalmological presentation of optic neuritis in myelin oligodendrocyte glycoprotein antibody-associated disease]

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Item Type:	Review
Title:	Neuroophthalmologische Präsentation der Retrobulbärneuritis im Rahmen der Myelin-Oligodendrozyten-Glykoprotein-Antikörper-assoziierten Erkrankung [Neuro-ophthalmological presentation of optic neuritis in myelin oligodendrocyte glycoprotein antibody-associated disease]
Creators Name:	Lin, T.Y., Asseyer, S., Buenrostro, G.S., Feldmann, K., Hamann, S., Paul, F. and Zimmermann, H.G.
Abstract:	Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a rare demyelinating autoimmune disorder of the central nervous system. MOGAD frequently manifests with severe, bilateral, and episodes of recurrent optic neuritis (ON) and is an important differential diagnosis to multiple sclerosis and aquaporin-4-IgG seropositive neuromyelitis optica spectrum disorders. Besides ON, the clinical manifestations of MOGAD commonly include transverse myelitis, acute disseminated encephalomyelitis, and brain stem encephalitis. In this review, we summarize the current knowledge of the neuro-ophthalmological presentation of MOGAD-ON. We describe epidemiological aspects, including the association with COVID-19 and other infections or vaccinations, clinical presentation, and imaging findings of MOGAD-ON in the acute stage and during remission. Furthermore, we report findings on prognosis, treatment response, and changes in ON-unaffected eyes. We touch upon findings on visual acuity, visual fields, and visual evoked potentials, as well as structural changes assessed with optical coherence tomography. Moreover, we explain how to differentiate MOGAD from its differential diagnoses, including other neuroinflammatory disorders (multiple sclerosis and neuromyelitis optica spectrum disorders), but also idiopathic intracranial hypertension.
Keywords:	Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease, Optic Neuritis, Optical Coherence Tomography, Visual Evoked Potential, Neuromyelitis Optica Spectrum Disorder
Source:	Klinische Monatsblatter fur Augenheilkunde
ISSN:	0023-2165
Publisher:	Thieme
Volume:	239
Number:	11
Page Range:	1305-1314
Date:	21 November 2022
Additional Information:	Copyright © 2022. Thieme. All rights reserved.
Official Publication:	https://doi.org/10.1055/a-1928-5117
PubMed:	View item in PubMed

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