A novel conditional Aire allele enables cell-specific ablation of the immune tolerance regulator Aire

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Item Type:	Letter
Title:	A novel conditional Aire allele enables cell-specific ablation of the immune tolerance regulator Aire
Creators Name:	Dobeš, J., Edenhofer, F., Vobořil, M., Brabec, T., Dobešová, M., Čepková, A., Klein, L., Rajewsky, K. and Filipp, D.
Abstract:	Medullary thymic epithelial cell (mTEC)-restricted expression of autoimmune regulator (Aire) is essential for establishment of immune tolerance. Recently, Aire was also shown to be expressed in cells of hematopietic and reproductive lineages. Thus, the generation of Aire(fl/fl) mouse strain enables the investigation of the cell-specific function of Aire.
Keywords:	Aire, Conditional Knockout, Immune Tolerance, Medullary Thymic Epithelial Cells, Animals, Mice
Source:	European Journal of Immunology
ISSN:	0014-2980
Publisher:	Wiley
Volume:	48
Number:	3
Page Range:	546-548
Date:	March 2018
Official Publication:	https://doi.org/10.1002/eji.201747267
PubMed:	View item in PubMed

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