New avenues for genetics guided therapeutic approaches in AML

Tools

Item Type:	Review
Title:	New avenues for genetics guided therapeutic approaches in AML
Creators Name:	Bullinger, L.
Abstract:	The development of single nucleotide polymorphism (SNP) microarray analysis and next generation sequencing (NGS) has significantly contributed to comprehensively characterize the genetic changes underlying acute myeloid leukemia (AML). These genomics technologies have led to the identification of an increasing number of genomic aberrations and gene mutations that cause epigenetic changes and lead to deregulated gene expression. In accordance, AML patients present with a distinct and almost individual combination of somatically acquired genetic alterations reflecting the molecular heterogeneity of the disease. Some of these are known driver mutations perturbing self-renewal, proliferation, and hematopoietic differentiation, whereas many mutations also represent mere passenger events, which do not significantly contribute to AML. In the future, we will have to discriminate driver from passenger mutations and in addition it will be crucial to evaluate the prognostic and predictive values of the respective driver mutations, especially in the context of the overall genetic background. While first genetic markers have already been translated into the daily clinical routine by impacting treatment decisions, novel biomarkers are needed especially to improve the effectiveness of molecular targeted therapies, which have to be put into the perspective of mutational networks to further “precision medicine” by personalized combination treatment approaches.
Keywords:	Acute Myeloid Leukemia, Cytogenetics, Molecular Genetics, Genomics, Next Generation Sequencing, Targeted Therapy, Risk-Adapted Therapy, Animals
Source:	Acta Haematologica Polonica
ISSN:	0001-5814
Publisher:	Via Medica
Volume:	45
Number:	4
Page Range:	322-329
Date:	1 October 2014
Official Publication:	https://doi.org/10.1016/j.achaem.2014.05.001

Repository Staff Only: item control page