Transcriptional mechanisms of pancreatic β-cell maturation and functional adaptation

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Item Type:	Review
Title:	Transcriptional mechanisms of pancreatic β-cell maturation and functional adaptation
Creators Name:	Wortham, M. and Sander, M.
Abstract:	Pancreatic β-cells secrete insulin commensurate to circulating nutrient levels to maintain normoglycemia. The ability of β-cells to couple insulin secretion to nutrient stimuli is acquired during a postnatal maturation process. In mature β-cells the insulin secretory response adapts to changes in nutrient state. Both β-cell maturation and functional adaptation rely on the interplay between extracellular cues and cell type-specific transcriptional programs. Here we review emerging evidence that developmental and homeostatic regulation of β-cell function involves collaboration between lineage-determining and signal-dependent transcription factors (LDTFs and SDTFs, respectively). A deeper understanding of β-cell SDTFs and their cognate signals would delineate mechanisms of β-cell maturation and functional adaptation, which has direct implications for diabetes therapies and for generating mature β-cells from stem cells.
Keywords:	Cell Differentiation, Insulin, Insulin Secretion, Insulin-Secreting Cells, Stem Cells
Source:	Trends in Endocrinology and Metabolism
ISSN:	1043-2760
Publisher:	Elsevier
Volume:	32
Number:	7
Page Range:	474-487
Date:	July 2021
Official Publication:	https://doi.org/10.1016/j.tem.2021.04.011
PubMed:	View item in PubMed

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