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| Item Type: | Article |
|---|---|
| Title: | The MafA transcription factor appears to be responsible for tissue-specific expression of insulin |
| Creators Name: | Matsuoka, T., Artner, I., Henderson, E., Means, A., Sander, M. and Stein, R. |
| Abstract: | Insulin gene expression is regulated by several islet-enriched transcription factors. However, MafA is the only beta cell-specific activator. Here, we show that MafA selectively induces endogenous insulin transcription in non-beta cells. MafA was also first detected in the insulin-producing cells formed during the second and predominant phase of beta cell differentiation, and absent in the few insulin-positive cells found in Nkx6.1(-/-) pancreata, which lack the majority of second-phase beta cells. These results demonstrate that MafA is a potent insulin activator that is likely to function downstream of Nkx6.1 during islet insulin-producing cell development. |
| Keywords: | Base Sequence, Cell Line, DNA Primers, Gene Expression Regulation, Immunohistochemistry, Insulin, Islets of Langerhans, C-Type Lectins, Large Maf Transcription Factors, Molecular Sequence Data, Organ Specificity, Immunologic Receptors, Recombinant Proteins, Trans-Activators, Transcription Factors, Transfection, Animals, Mice, Rats |
| Source: | Proceedings of the National Academy of Sciences of the United States of America |
| ISSN: | 0027-8424 |
| Publisher: | National Academy of Sciences |
| Volume: | 101 |
| Number: | 9 |
| Page Range: | 2930-3 |
| Date: | 2 March 2004 |
| Official Publication: | https://doi.org/10.1073/pnas.0306233101 |
| PubMed: | View item in PubMed |
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