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| Item Type: | Article |
|---|---|
| Title: | Immunological and pathological outcomes of SARS-CoV-2 challenge following formalin-inactivated vaccine in ferrets and rhesus macaques |
| Creators Name: | Bewley, K.R., Gooch, K., Thomas, K.M., Longet, S., Wiblin, N., Hunter, L., Chan, K., Brown, P., Russell, R. A., Ho, C., Slack, G., Humphries, H.E., Alden, L., Allen, L., Aram, M., Baker, N., Brunt, E., Cobb, R., Fotheringham, S., Harris, D., Kennard, C., Leung, S., Ryan, K., Tolley, H., Wand, N., White, A., Sibley, L., Sarfas, C., Pearson, G., Rayner, E., Xue, X., Lambe, T., Charlton, S., Gilbert, S., Sattentau, Q.J., Gleeson, F., Hall, Y., Funnell, S., Sharpe, S., Salguero, F.J., Gorringe, A. and Carroll, M. |
| Abstract: | There is an urgent requirement for safe and effective vaccines to prevent COVID-19. A concern for the development of new viral vaccines is the potential to induce vaccine-enhanced disease (VED). This was reported in several preclinical studies with both SARS-CoV-1 and MERS vaccines but has not been reported with SARS-CoV-2 vaccines. We have used ferrets and rhesus macaques challenged with SARS-CoV-2 to assess the potential for VED in animals vaccinated with formaldehyde-inactivated SARS-CoV-2 (FIV) formulated with Alhydrogel, compared to a negative control vaccine. We showed no evidence of enhanced disease in ferrets or rhesus macaques given FIV except for mild transient enhanced disease seen 7 days after infection in ferrets. This increased lung pathology was observed at day 7 but was resolved by day 15. We also demonstrate that formaldehyde treatment of SARS-CoV-2 reduces exposure of the spike receptor binding domain providing a mechanistic explanation for suboptimal immunity. |
| Keywords: | Animals, Mustela putorius furo, Macaca mulatta |
| Source: | Science Advances |
| ISSN: | 2375-2548 |
| Publisher: | American Association for the Advancement of Science |
| Volume: | 7 |
| Number: | 37 |
| Page Range: | eabg7996 |
| Date: | 10 September 2021 |
| Official Publication: | https://doi.org/10.1126/sciadv.abg7996 |
| PubMed: | View item in PubMed |
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