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Envelope glycoprotein trimers as HIV-1 vaccine immunogens

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Item Type:Review
Title:Envelope glycoprotein trimers as HIV-1 vaccine immunogens
Creators Name:Sattentau, Q.J.
Abstract:The HIV-1 envelope glycoprotein spike is the target of neutralizing antibody attack, and hence represents the only relevant viral antigen for antibody-based vaccine design. Various approaches have been attempted to recapitulate Env in membrane-anchored and soluble forms, and these will be discussed here in the context of recent successes and challenges still to be overcome.
Keywords:HIV-1, Vaccine, Neutralizing Antibodies, Envelope Glycoproteins, Trimer
Source:Vaccines
ISSN:2076-393X
Publisher:MDPI
Volume:1
Number:4
Page Range:497-512
Date:28 October 2013
Official Publication:https://doi.org/10.3390/vaccines1040497
PubMed:View item in PubMed

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