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| Item Type: | Article |
|---|---|
| Title: | Macrophage infection via selective capture of HIV-1-infected CD4(+) T cells |
| Creators Name: | Baxter, A.E., Russell, R.A., Duncan, C.J.A., Moore, M.D., Willberg, C.B., Pablos, J.L., Finzi, A., Kaufmann, D.E., Ochsenbauer, C., Kappes, J.C., Groot, F. and Sattentau, Q.J. |
| Abstract: | Macrophages contribute to HIV-1 pathogenesis by forming a viral reservoir and mediating neurological disorders. Cell-free HIV-1 infection of macrophages is inefficient, in part due to low plasma membrane expression of viral entry receptors. We find that macrophages selectively capture and engulf HIV-1-infected CD4(+) T cells leading to efficient macrophage infection. Infected T cells, both healthy and dead or dying, were taken up through viral envelope glycoprotein-receptor-independent interactions, implying a mechanism distinct from conventional virological synapse formation. Macrophages infected by this cell-to-cell route were highly permissive for both CCR5-using macrophage-tropic and otherwise weakly macrophage-tropic transmitted/founder viruses but restrictive for nonmacrophage-tropic CXCR4-using virus. These results have implications for establishment of the macrophage reservoir and HIV-1 dissemination in vivo. |
| Keywords: | CD4-Positive T-Lymphocytes, Cell Line, HIV Infections, HIV Receptors, HIV-1, Macrophages, Viral Envelope Proteins, Viral Tropism |
| Source: | Cell Host & Microbe |
| ISSN: | 1934-6069 |
| Publisher: | Cell Press |
| Volume: | 16 |
| Number: | 6 |
| Page Range: | 711-721 |
| Date: | 10 December 2014 |
| Official Publication: | https://doi.org/10.1016/j.chom.2014.10.010 |
| PubMed: | View item in PubMed |
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