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| Item Type: | Article |
|---|---|
| Title: | An interdisciplinary approach to characterize peanut-allergic patients - first data from the FOOD@ consortium |
| Creators Name: | Worm, M., Alexiou, A., Höfer, V., Birkner, T., Jeanrenaud, A.C.S.N., Fauchère, F., Pazur, K., Steinert, C., Arnau-Soler, A., Banerjee, P., Diefenbach, A., Dobbertin-Welsch, J., Dölle-Bierke, S., Francuzik, W., Ghauri, A., Heller, S., Kalb, B., Löber, U., Marenholz, I., Markó, L., Scheffel, J., Potapenko, O., Roll, St., Lau, S., Lee, Y.A., Braun, J., Thiel, A., Babina, M., Altrichter, S., Forslund, S.K. and Beyer, K. |
| Abstract: | BACKGROUND: Peanut allergy is a frequent cause of food allergy and potentially life-threatening. Within this interdisciplinary research approach, we aim to unravel the complex mechanisms of peanut allergy. As a first step were applied in an exploratory manner the analysis of peanut allergic versus non-allergic controls. METHODS: Biosamples were studied regarding DNA methylation signatures, gut microbiome, adaptive and innate immune cell populations, soluble signaling molecules and allergen-reactive antibody specificities. We applied a scalable systems medicine computational workflow to the assembled data. RESULTS: We identified combined cellular and soluble biomarker signatures that stratify donors into peanut-allergic and non-allergic with high specificity. DNA methylation profiling revealed various genes of interest and stool microbiota differences in bacteria abundances. CONCLUSION: By extending our findings to a larger set of patients (e.g., children vs. adults), we will establish predictors for food allergy and tolerance and translate these as for example, indicators for interventional studies. |
| Keywords: | Biomarker, Epigenetics, Food Allergy, Microbiome, Peanut Allergy |
| Source: | Clinical and Translational Allergy |
| ISSN: | 2045-7022 |
| Publisher: | Wiley |
| Volume: | 12 |
| Number: | 10 |
| Page Range: | e12197 |
| Date: | October 2022 |
| Official Publication: | https://doi.org/10.1002/clt2.12197 |
| PubMed: | View item in PubMed |
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