An interdisciplinary approach to characterize peanut-allergic patients - first data from the FOOD@ consortium

Worm, M.; Alexiou, A.; Höfer, V.; Birkner, T.; Jeanrenaud, A.C.S.N.; Fauchère, F.; Pazur, K.; Steinert, C.; Arnau-Soler, A.; Banerjee, P.; Diefenbach, A.; Dobbertin-Welsch, J.; Dölle-Bierke, S.; Francuzik, W.; Ghauri, A.; Heller, S.; Kalb, B.; Löber, U.; Marenholz, I.; Markó, L.; Scheffel, J.; Potapenko, O.; Roll, St.; Lau, S.; Lee, Y.A.; Braun, J.; Thiel, A.; Babina, M.; Altrichter, S.; Forslund, S.K.; Beyer, K.

An interdisciplinary approach to characterize peanut-allergic patients - first data from the FOOD@ consortium

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Item Type:	Article
Title:	An interdisciplinary approach to characterize peanut-allergic patients - first data from the FOOD@ consortium
Creators Name:	Worm, M., Alexiou, A., Höfer, V., Birkner, T., Jeanrenaud, A.C.S.N., Fauchère, F., Pazur, K., Steinert, C., Arnau-Soler, A., Banerjee, P., Diefenbach, A., Dobbertin-Welsch, J., Dölle-Bierke, S., Francuzik, W., Ghauri, A., Heller, S., Kalb, B., Löber, U., Marenholz, I., Markó, L., Scheffel, J., Potapenko, O., Roll, St., Lau, S., Lee, Y.A., Braun, J., Thiel, A., Babina, M., Altrichter, S., Forslund, S.K. and Beyer, K.
Abstract:	BACKGROUND: Peanut allergy is a frequent cause of food allergy and potentially life-threatening. Within this interdisciplinary research approach, we aim to unravel the complex mechanisms of peanut allergy. As a first step were applied in an exploratory manner the analysis of peanut allergic versus non-allergic controls. METHODS: Biosamples were studied regarding DNA methylation signatures, gut microbiome, adaptive and innate immune cell populations, soluble signaling molecules and allergen-reactive antibody specificities. We applied a scalable systems medicine computational workflow to the assembled data. RESULTS: We identified combined cellular and soluble biomarker signatures that stratify donors into peanut-allergic and non-allergic with high specificity. DNA methylation profiling revealed various genes of interest and stool microbiota differences in bacteria abundances. CONCLUSION: By extending our findings to a larger set of patients (e.g., children vs. adults), we will establish predictors for food allergy and tolerance and translate these as for example, indicators for interventional studies.
Keywords:	Biomarker, Epigenetics, Food Allergy, Microbiome, Peanut Allergy
Source:	Clinical and Translational Allergy
ISSN:	2045-7022
Publisher:	Wiley
Volume:	12
Number:	10
Page Range:	e12197
Date:	October 2022
Official Publication:	https://doi.org/10.1002/clt2.12197
PubMed:	View item in PubMed

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