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Blood flow meets mitophagy

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Item Type:Editorial
Title:Blood flow meets mitophagy
Creators Name:Akmeriç, E.B. and Gerhardt, H.
Abstract:Since its discovery as a mechanosensitive transcription factor in endothelial networks, Klf2's varying expression levels under different blood flow patterns remained a mystery. In this study, Coon et al. (2022. J. Cell Biol.https://doi.org/10.1083/jcb.202109144) discover a connection between sustained laminar shear stress and mitochondrial flux that contributes to Klf2's transcriptional dynamics.
Keywords:Cell Metabolism, Cell Signaling, Disease, Metabolism, Animals, Mice
Source:Journal of Cell Biology
ISSN:0021-9525
Publisher:Rockefeller University Press
Volume:221
Number:7
Page Range:e202206033
Date:4 July 2022
Official Publication:https://doi.org/10.1083/jcb.202206033
PubMed:View item in PubMed

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