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Wie Kochsalz Mitochondrien beeinflusst

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Item Type:Review
Title:Wie Kochsalz Mitochondrien beeinflusst
Creators Name:Geisberger, S.
Abstract:Dietary high salt (HS) is a major risk factor for cardio-vascular and chronic inflammatory diseases. Sodium can increase postprandially but can also accumulate in diverse tissues. Immune cells, such as macrophages, sense this salty environment and adapt accordingly, shifting towards a more pro-inflammatory state. Mechanistically, HS inhibits complex II of the electron transport chain and thereby reduces mitochondrial function. In two independent clinical studies, an HS-diet transiently impaired human monocytic mitochondrial function.
Source:BIOspektrum
ISSN:0947-0867
Publisher:Springer / Spektrum Akademischer Verlag
Volume:28
Number:4
Page Range:387-389
Date:June 2022
Official Publication:https://doi.org/10.1007/s12268-022-1781-y

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