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| Item Type: | Article |
|---|---|
| Title: | SOX9 duplication linked to intersex in deer |
| Creators Name: | Kropatsch, R., Dekomien, G., Akkad, D.A., Gerding, W.M., Petrasch-Parwez, E., Young, N.D., Altmüller, J., Nürnberg, P., Gasser, R.B. and Epplen, J.T. |
| Abstract: | A complex network of genes determines sex in mammals. Here, we studied a European roe deer with an intersex phenotype that was consistent with a XY genotype with incomplete male-determination. Whole genome sequencing and quantitative real-time PCR analyses revealed a triple dose of the SOX9 gene, allowing insights into a new genetic defect in a wild animal. |
| Keywords: | DNA Copy Number Variations, Disorders of Sex Development, Gene Duplication, Genetic Variation, Genotype, Molecular Sequence Data, Phenotype, Polymerase Chain Reaction, SOX9 Transcription Factor, DNA Sequence Analysis, Animals, Deer |
| Source: | PLoS ONE |
| ISSN: | 1932-6203 |
| Publisher: | Public Library of Science |
| Volume: | 8 |
| Number: | 9 |
| Page Range: | e73734 |
| Date: | 6 September 2013 |
| Official Publication: | https://doi.org/10.1371/journal.pone.0073734 |
| PubMed: | View item in PubMed |
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