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| Item Type: | Article |
|---|---|
| Title: | Circulating HLA-G and its association with cardiovascular markers in pregnancy |
| Creators Name: | Lekva, T., Jacobsen, D.P., Sugulle, M., Moe, K., Fjeldstad, H.E.S., Dechend, R. and Staff, A.C. |
| Abstract: | Human Leukocyte Antigen-G (HLA-G) prevents the activity of immune cells and is decreased in women with preeclampsia. We aimed to investigate the associations between circulating soluble HLA-G (sHLA-G) and 92 cardiovascular disease-related biomarkers from a previously published multiplex study in women with preeclampsia and controls. We found 15 markers significantly associated with circulating sHLA-G in univariate analyses. After multivariable adjusted regression, only proto-oncogene tyrosine-protein kinase Src (SRC) and vascular endothelial growth factor D were significantly associated with sHLA-G. Low SRC, previously observed in the circulation of preeclamptic women, may be regulated by low sHLA-G, and reflect decreased trophoblast differentiation and syncytical formation. |
| Keywords: | Preeclampsia, CVD, SRC, VEGFD, Multiplex |
| Source: | Journal of Reproductive Immunology |
| ISSN: | 0165-0378 |
| Publisher: | Elsevier |
| Volume: | 146 |
| Page Range: | 103331 |
| Date: | August 2021 |
| Official Publication: | https://doi.org/10.1016/j.jri.2021.103331 |
| PubMed: | View item in PubMed |
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