![[feed]](/style/images/feed-icon-14x14.png){kind=icon}
Tools
Tools
Preview |
PDF (Original Article)
- Requires a PDF viewer such as GSview, Xpdf or Adobe Acrobat Reader
2MB |
| Item Type: | Editorial |
|---|---|
| Title: | Therapy-induced senescence: opportunities to improve anticancer therapy |
| Creators Name: | Prasanna, P.G., Citrin, D.E., Hildesheim, J., Ahmed, M.M., Venkatachalam, S., Riscuta, G., Xi, D., Zheng, G., van Deursen, J., Goronzy, J., Kron, S.J., Anscher, M.S., Sharpless, N.E., Campisi, J., Brown, S.L., Niedernhofer, L.J., O'Loghlen, A., Georgakilas, A.G., Paris, F., Gius, D., Gewirtz, D.A., Schmitt, C.A., Abazeed, M.E., Kirkland, J.L., Richmond, A., Romesser, P.B., Lowe, S.W., Gil, J., Mendonca, M.S., Burma, S., Zhou, D. and Coleman, C.N. |
| Abstract: | Cellular senescence is an essential tumor suppressive mechanism that prevents the propagation of oncogenically activated, genetically unstable, and/or damaged cells. Induction of tumor cell senescence is also one of the underlying mechanisms by which cancer therapies exert antitumor activity. However, an increasing body of evidence from preclinical studies demonstrates that radiation and chemotherapy cause accumulation of senescent cells (SnCs) both in tumor and normal tissue. SnCs in tumors can, paradoxically, promote tumor relapse, metastasis, and resistance to therapy, in part, through expression of the senescence-associated secretory phenotype. In addition, SnCs in normal tissue can contribute to certain radiation- and chemotherapy-induced side effects. Because of its multiple roles, cellular senescence could serve as an important target in the fight against cancer. This commentary provides a summary of the discussion at the National Cancer Institute Workshop on Radiation, Senescence, and Cancer (August 10-11, 2020, National Cancer Institute, Bethesda, MD) regarding the current status of senescence research, heterogeneity of therapy-induced senescence, current status of senotherapeutics and molecular biomarkers, a concept of "one-two punch" cancer therapy (consisting of therapeutics to induce tumor cell senescence followed by selective clearance of SnCs), and its integration with personalized adaptive tumor therapy. It also identifies key knowledge gaps and outlines future directions in this emerging field to improve treatment outcomes for cancer patients. |
| Keywords: | Cancer, Cancer Therapy, Radiation, Radiation Therapy, Senescence, Aging, "One-Two Punch" Cancer Therapy, Therapy-Induced Senescence, Senotherapeutics, Senolytics, Senomorphics |
| Source: | Journal of the National Cancer Institute |
| ISSN: | 0027-8874 |
| Publisher: | Oxford University Press |
| Volume: | 113 |
| Number: | 10 |
| Page Range: | 1285-1298 |
| Date: | October 2021 |
| Additional Information: | Erratum in: J Natl Cancer Inst 113(10): 1285-1298. |
| Official Publication: | https://doi.org/10.1093/jnci/djab064 |
| PubMed: | View item in PubMed |
Repository Staff Only: item control page
